• PTT > 5 sec above control
  • Serum albumin < 2.5 g/dL
  • Ascites despite diuretics
  • Peritonitis
  • Hepatorenal syndrome
  • Encephalopathy
  • Recurrent variceal bleeding
  • Supporting indicators:
    • Malnutrition
    • Muscle wasting
    • Hepatitis C
    • Active alcoholism